USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PHB_HUMAN USC-OGP 2-DE database:  PHB_HUMAN PHB_HUMAN General information about the entry View entry in simple text format Entry name PHB_HUMAN Primary accession number P35232 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Prohibitin;. Gene name Name=PHB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0501: pI=5.34; Mw=28252 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0786: pI=5.31; Mw=29986 Cross-references UniProtKB/Swiss-Prot P35232; PHB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PHB_HUMAN Primary accession number P35232 Secondary accession number(s) B4DY47 Q4VBQ0 Sequence was last modified on  February 1, 1994 (version 1) Annotations were last modified on  March 15, 2017 (version 170) Name and origin of the protein Description RecName: Full=Prohibitin; Gene name Name=PHB Encoded on Name=PHB Keywords 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; DNA synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL S85655; AAB21614.1; -; mRNA EMBL L14272; AAO18340.1; -; Genomic_DNA EMBL BT007411; AAP36079.1; -; mRNA EMBL AK302258; BAG63609.1; -; mRNA EMBL AC091180; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC013401; AAH13401.1; -; mRNA EMBL BC095460; AAH95460.1; -; mRNA CCDS CCDS11548.1; -. [P35232-1]; . CCDS CCDS62244.1; -. [P35232-2]; . PIR I52690; I52690; . RefSeq NP_001268425.1; NM_001281496.1. [P35232-1]; . RefSeq NP_001268426.1; NM_001281497.1. [P35232-2]; . RefSeq NP_001268644.1; NM_001281715.1. [P35232-1]; . RefSeq NP_002625.1; NM_002634.3. [P35232-1]; . RefSeq XP_016880252.1; XM_017024763.1. [P35232-1]; . UniGene Hs.514303; -; . PDB 1LU7; Model; -; A=1-272 PDBsum 1LU7; -; . ProteinModelPortal P35232; -; . SMR P35232; -; . BioGrid 111264; 153; . DIP DIP-24248N; -; . IntAct P35232; 94; . MINT MINT-1158239; -; . STRING 9606.ENSP00000300408; -; . iPTMnet P35232; -; . PhosphoSitePlus P35232; -; . SwissPalm P35232; -; . DMDM 464371; -; . DOSAC-COBS-2DPAGE P35232; -; . OGP P35232; -; . REPRODUCTION-2DPAGE IPI00017334; -; . REPRODUCTION-2DPAGE P35232; -; . SWISS-2DPAGE P35232; -; . UCD-2DPAGE P35232; -; . EPD P35232; -; . MaxQB P35232; -; . PaxDb P35232; -; . PeptideAtlas P35232; -; . PRIDE P35232; -; . TopDownProteomics P35232-1; -. [P35232-1]; . DNASU 5245; -; . Ensembl ENST00000300408; ENSP00000300408; ENSG00000167085. [P35232-1]; . Ensembl ENST00000511832; ENSP00000425035; ENSG00000167085. [P35232-2]; . Ensembl ENST00000614445; ENSP00000479488; ENSG00000167085. [P35232-1]; . Ensembl ENST00000617874; ENSP00000484113; ENSG00000167085. [P35232-1]; . GeneID 5245; -; . KEGG hsa:5245; -; . UCSC uc002iox.3; human. [P35232-1]; . CTD 5245; -; . DisGeNET 5245; -; . GeneCards PHB; -; . HGNC HGNC:8912; PHB; . HPA HPA003280; -; . MalaCards PHB; -; . MIM 176705; gene; . neXtProt NX_P35232; -; . OpenTargets ENSG00000167085; -; . PharmGKB PA33251; -; . eggNOG KOG3083; Eukaryota; . eggNOG COG0330; LUCA; . GeneTree ENSGT00550000074770; -; . HOGENOM HOG000205692; -; . HOVERGEN HBG004457; -; . InParanoid P35232; -; . KO K17080; -; . OMA TMANEKQ; -; . OrthoDB EOG091G0IHW; -; . PhylomeDB P35232; -; . TreeFam TF300095; -; . Reactome R-HSA-5673000; RAF activation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . GeneWiki Prohibitin; -; . GenomeRNAi 5245; -; . PRO PR:P35232; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000167085; -; . CleanEx HS_PHB; -; . ExpressionAtlas P35232; baseline and differential; . Genevisible P35232; HS; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0005769; C:early endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005887; C:integral component of plasma membrane; IDA:HGNC; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0001850; F:complement component C3a binding; IDA:UniProtKB; . GO GO:0001851; F:complement component C3b binding; IDA:UniProtKB; . GO GO:0019899; F:enzyme binding; IPI:BHF-UCL; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0031871; F:proteinase activated receptor binding; IPI:UniProtKB; . GO GO:0000981; F:RNA polymerase II transcription factor activity; sequence-specific DNA binding; IEA:Ensembl GO GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; . GO GO:0071354; P:cellular response to interleukin-6; IDA:BHF-UCL; . GO GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW; . GO GO:0016575; P:histone deacetylation; IDA:UniProtKB; . GO GO:0007005; P:mitochondrion organization; IMP:UniProtKB; . GO GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:BHF-UCL; . GO GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL; . GO GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL; . GO GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB; . GO GO:2000323; P:negative regulation of glucocorticoid receptor signaling pathway; IDA:BHF-UCL; . GO GO:0042177; P:negative regulation of protein catabolic process; IMP:UniProtKB; . GO GO:0010944; P:negative regulation of transcription by competitive promoter binding; IDA:BHF-UCL; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0001649; P:osteoblast differentiation; IDA:UniProtKB; . GO GO:0010942; P:positive regulation of cell death; IGI:ParkinsonsUK-UCL; . GO GO:0045917; P:positive regulation of complement activation; IDA:UniProtKB; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB; . GO GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IMP:UniProtKB; . GO GO:0010628; P:positive regulation of gene expression; IGI:ParkinsonsUK-UCL; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL; . GO GO:0050821; P:protein stabilization; IMP:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB; . GO GO:0006355; P:regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0007165; P:signal transduction; TAS:UniProtKB; . CDD cd03401; SPFH_prohibitin; 1; . InterPro IPR001107; Band_7; . InterPro IPR000163; Prohibitin; . PANTHER PTHR23222; PTHR23222; 1; . Pfam PF01145; Band_7; 1; . PRINTS PR00679; PROHIBITIN; . SMART SM00244; PHB; 1; . SUPFAM SSF117892; SSF117892; 1; .

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